Stem Cells and Cancer

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the idea that cancer arises from stem cells was first proposed more than 150 years as an embryonic rest theory of cancer. However, in the early 20th century, embryonal rest theory of cancer has been rejected, a hypothesis that cancer arises from the de-differentiation has become widely accepted. Then, about 50 years, studies on cancer tissue Germinal (teratocarcinomas) re-established principle that cancer arises from stem cytes, and that cancer can be treated with induction of differentiation (differentiation therapy). However, teratocarcinomas were considered exceptions to the rule, a de-differentiation theories about the origin remained largely accepted for most cancers to 1980 S. then study the cellular origin of cancer during experimental chemical hepatocarcinogenesis showed that hepatocellular carcinoma is derived from de differentiation of hepatocytes, as well as generally believed, but from the maturation arrest in hepatocyte cytes roda.Ponovno appearance of cells of the theory of cancer preceded the current excitement in cancer.

the idea that cancer arises from stem cells was first proposed more than 150 years as an embryonic rest theory of cancer. However, in the early 20th century, embryonal rest theory of cancer has been rejected, a hypothesis that cancer arises from the de-differentiation has become widely accepted. Then, about 50 years, studies on cancer tissue Germinal (teratocarcinomas) re-established principle that cancer arises from stem cytes, and that cancer can be treated with induction of differentiation (differentiation therapy). However, teratocarcinomas were considered exceptions to the rule, a de-differentiation theories about the origin remained largely accepted for most cancers to 1980 S. then study the cellular origin of cancer during experimental chemical hepatocarcinogenesis showed that hepatocellular carcinoma is derived from de differentiation of hepatocytes, as well as generally believed, but from the maturation arrest in hepatocyte cytes roda.Ponovno appearance of cells of the theory of cancer preceded the current excitement in cancer.

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During the past 10 years, differentiation therapy has been applied with great success for blood cancer cytes (leukemia) is the inactivation of signaling pathways that allow leukemic transit boost to continue to multiply, and not die (maturation arrest). The differentiation of cancer treatment are now proposing the use of small molecules or inhibitory RNA inhibition (iRNAs) for blocking signals održavaju''stemness''so that leukemic tissues may vary. Conventional chemotherapy, radiation therapy, and anti-angiogenic therapies act on carcinomoa. When these therapies are discontinued, the cancer will re-form of therapy-resistant cancers. A successful differentiation therapy of cancer cells will power the station for the difference, so that they can not re-establish cancer.

origin of all tissue cells called stem cells. From this single cell produces new ostale.Oplođeno egg is primordial for all tissues of the human body. The direct descendants of the primordia of embryonic stem cells, which, in turn, lead to tissue. It is from these tissues that most cancers arise.

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of normal tissue and cancer tissue contain the same population

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transit-amplified cells

and terminally differentiated cells.

normal tissue renewal and cancer growth and achieved by dividing transit-amplifying cells. Normally, stem cells and normal tissue and cancer are relatively few, compared to the transit-amplifying and terminally differentiated cells, and they do not participate in those širenju.Razmnožavanje both cancer and normal tissues are transit-amplifying cells. Cancer tissue differs from normal tissue in the transit-amplifying cells accumulate in cancer, whereas in normal tissue differ, so that they no longer share (terminal differentiation ).

One of the best examples of a normal cell lineage and maturation arrest contributions for cancer kože.Pluripotentnih skin epidermal stem cells are found in the bulb of the follicle dlake.Epidermis-committed stem cells are located in the basal layer of the skin (germinativum) and are much less in the number of transit-amplifying cancer is in the spinosum layer. Maturation was achieved through the accumulation of cytokeratin, which became prominent in the granular sloj.Granule citokeratin.Citoplazmi containing cells in the granular layer is filled with these granules and ultimately into the cells lose their structure, forming the outer layer of acellular keratin, known as corneum.

One of the best examples of a normal cell lineage and maturation arrest contributions for cancer kože.Pluripotentnih skin epidermal stem cells are found in the bulb of the follicle dlake.Epidermis-committed stem cells are located in the basal layer of the skin (germinativum) and are much less in the number of transit-amplifying cancer is in the spinosum layer. Maturation was achieved through the accumulation of cytokeratin, which became prominent in the granular sloj.Granule citokeratin.Citoplazmi containing cells in the granular layer is filled with these granules and ultimately into the cells lose their structure, forming the outer layer of acellular keratin, known as corneum.

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One of the best examples of a normal cell lineage and maturation arrest contributions for cancer kože.Pluripotentnih skin epidermal stem cells are found in the bulb of the follicle dlake.Epidermis-committed stem cells are located in the basal layer of the skin (germinativum) and are much less in the number of transit-amplifying cancer is in the spinosum layer. Maturation was achieved through the accumulation of cytokeratin, which became prominent in the granular sloj.Granule citokeratin.Citoplazmi containing cells in the granular layer is filled with these granules and ultimately into the cells lose their structure, forming the outer layer of acellular keratin, known as corneum.

...

One of the best examples of a normal cell lineage and maturation arrest contributions for cancer kože.Pluripotentnih skin epidermal stem cells are found in the bulb of the follicle dlake.Epidermis-committed stem cells are located in the basal layer of the skin (germinativum) and are much less in the number of transit-amplifying cancer is in the spinosum layer. Maturation was achieved through the accumulation of cytokeratin, which became prominent in the granular sloj.Granule citokeratin.Citoplazmi containing cells in the granular layer is filled with these granules and ultimately into the cells lose their structure, forming the outer layer of acellular keratin, known as corneum.

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